Nephrogenic Diabetes Insipidus

Water! Water! Everywhere! Diagnosis and Management of Nephrogenic Diabetes Insipidus

Goals: 1. Understand diabetes insipidus and the role of arginine vasopressin production and its role at the kidney 2. Understand how to differentiate nephrogenic diabetes insipidus from central diabetes insipidus and primary polydipsia 3. Understand the etiology of nephrogenic diabetes insipidus 4. Understand the available diagnostic tools and their usefulness in characterizing the picture of n...

Lithium-induced nephrogenic diabetes insipidus.

BACKGROUND Lithium can cause nephrogenic diabetes insipidus in up to 20 to 40 percent of patients currently taking the medication, and a subset of these patients will have a persistent concentrating defect long after lithium is discontinued. They are at risk for serious hypernatremia when fluid intake is restricted for any reason. METHODS MEDLINE as used to search the key words "nephrogenic d...

Nephrogenic diabetes insipidus and Werdnig-Hoffmann disease in a child: an unusual association.

The unusual association of Werdnig-Hoffmann disease and nephrogenic diabetes insipidus in a 5-month-old child is described for the first time. The association is casual, considering the different pathways of genetical transmission in these two diseases. The possibility of identifying the heterozygote is discussed and it appears to be limited to nephrogenic diabetes insipidus.

Persistent nephrogenic diabetes insipidus, tubular proteinuria, aminoaciduria, and parathyroid hormone resistance following longterm lithium administration.

We report a patient who developed persistent nephrogenic diabetes insipidus associated with renal tubular acidosis, renal resistance to parathyroid hormone, aminoaciduria and proximal tubule pattern proteinuria in the presence of a reduced glomerular filtration rate (19-24 ml/min). A review of the previous reports of persistent nephrogenic diabetes insipidus revealed that in all patients the gl...

Persistent nephrogenic diabetes insipidus, hyperparathyroidism, and hypothyroidism after lithium treatment.

Congenital nephrogenic diabetes insipidus in the Corpus Hippocraticum: The first description.

In congenital nephrogenic diabetes insipidus (cNDI), polyuria and polydipsia are present from birth, as the kidney is unable to concentrate urine despite elevated concentrations of the antidiuretic hormone arginine-vasopressin.1 In ancient Greek medicine, physiology was, needless, to say, an as yet fairly undeveloped specialty among medico-philosophers, based as they were mainly on the Hippocra...